John Libbey Eurotext

Gériatrie et Psychologie Neuropsychiatrie du Vieillissement


Protein supplementation to prevent loss in muscle mass and strength in frail older patients: a review Volume 17, issue 2, Juin 2019

1 Membres du Groupe Expert Nutrition en Gériatrie (GEGN) sous l’égide de la SFGG
2 Service de médecine gériatrique, CHU Lyon, Groupement Hospitalier Sud, Pierre-Bénite, France
3 Inserm U1060, Oullins, France
4 Département de santé publique et d’épidémiologie, Université de Liège, Belgique
5 Service de médecine gériatrique, Groupe hospitalier Albert Chenevier-Henri Mondor, AP-HP, Créteil, France
6 Service de médecine gériatrique, Hôpital Bichat, AP-HP, Paris, France
7 Service de médecine gériatrique, CHU Nice, France
8 Centre de gérontologie clinique Antonin Balmes, CHU Montpellier, France
9 CHU Clermont-Ferrand, France
10 Service de médecine gériatrique, Centre Hospitalier Villefranche-sur-Saône, France
11 UMR U 557, Inserm U1125 - Inra/Cnam, Paris, France
12 Gérontopôle, CHU Toulouse, Inserm UMR 1027, France
13 Service de médecine gériatrique, Hôpital Bellier, CHU Nantes, France
* Correspondance

Minimum levels of protein intake are essential for the preservation of muscle mass and function, which is a major preventive issue of successful aging. Epidemiological studies suggest strong associations between protein intake and the different elements of sarcopenia, namely maintenance of lean mass and muscle strength. Most often, protein intakes among older patients are below requirements, independently from situations of under nutrition. This opens the path for nutritional interventions to prevent the consequences of sarcopenia in older patients. Isolated amino-acids such as leucine have shown positive effects in the short term only. The positive effects of protein supplementations on muscle strength and function are currently not established in the absence of concomitant exercise training. The highest level of evidence supports interventions combining exercise and nutrition.