John Libbey Eurotext

Annales de Biologie Clinique


Usefulness of immature platelet fraction measurement for diagnosis and monitoring of iron deficiency associated thrombocytopenia: about two cases Volume 78, issue 4, Juillet-Août 2020


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1 Université de Paris, Hôpital européen Georges Pompidou, AP-HP, Service d’hématologie biologique, Paris, France
2 Université de Paris, Innovative Therapies in Haemostasis, Inserm 1140, Paris, France
3 Université de Paris, Hôpital européen Georges Pompidou, AP-HP, Service de médecine interne, Paris, France
* Correspondance

Iron deficiency anemia is frequently associated with thrombocytosis. However, in some rare cases of very severe iron deficiency, a thrombocytopenia may occur. This condition may lead to a misdiagnosis of immune thrombocytopenic purpura and thus to unnecessary tests in this context. Here we report two patients who presented with iron deficiency associated thrombocytopenia rapidly corrected after martial supplementation. We then discuss the value of measuring immature platelet fraction (IPF), which represents the population of newly formed platelets containing a greater amount of residual RNA. For both cases, low IPF values at admission indicated a central origin of thrombocytopenia with decreased platelet production, which is the pathophysiological mechanism of iron deficiency associated thrombocytopenia.