JLE

Revue de neuropsychologie

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Memory and consolidation: contribution of transient epileptic amnesia Volume 9, issue 4, Octobre-Novembre-Décembre 2017

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Authors
1 Pôle de neurosciences cliniques,
service de neurologie et neuropsychologie,
CHU de la Timone,
AP des Hôpitaux de Marseille,
264, rue Saint-Pierre,
13385 Marseille cedex 5, France
2 Aix Marseille Université,
INS UMR_S 1106,
13005, Marseille, France
* Correspondance

Modern consolidation theories suggest that new memories are initially labile before undergoing a series of transformation that render the memory representations progressively more stable. The study of consolidation memory in the brain-damaged human is hampered by the temporal decay of forgetting which, occurring in the next minutes following the acquisition of information, prevents the characterization of the chain of processes occurring thereafter. Over the past several years however, a novel epileptic syndrome has been individualized in patients with temporal lobe epilepsy. This syndrome endorses singular neuropsychological (autobiographical lacune covering the past 5-10 years, long-term anterograde memory loss), neurophysiological (inter-ictal epileptiform activity during slow wave sleep) and anatomical (hippocampal dysfunction) characteristics, and constitutes a suitable pathological model for consolidation memory study. It provides a new perspective on the main theoretical consolidation memory framework, pleading in favor of Multiple Trace Theory model, and on the role of sleep in the hippocampo-neocortical dialogue necessary to the building and maintenance of memory trace.