John Libbey Eurotext

Médecine de la Reproduction


The impact of female infertility on the occurrence of congenital malformations after assisted reproduction Volume 24, issue 1, Janvier-Février-Mars 2022


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1 Hôpital de Dijon, université de Bourgogne-Franche-Comté, laboratoire de biologie de la reproduction-Cecos, Dijon, France
2 Unilabs, direction médicale, Clichy-La-Garenne, France
3 Centre d’assistance médicale à la procréation, biologie de la reproduction, CHU Amiens, France
4 Centre d’assistance médicale à la procréation, gynécologie obstétrique, médecine de la reproduction, université Paris 7 Diderot, groupe hospitalier Bichat Claude-Bernard, AP-HP, Paris, France
5 Service de médecine et biologie de la reproduction, hôpital Saint-Joseph, Marseille, France
6 Inserm, équipe lipodystrophies génétiques et acquises, service de biologie de la reproduction-CECOS, Saint-Antoine Research center, Sorbonne université, hôpital Tenon, AP-HP, Paris, France
7 Diagnostic anténatal, gynécologie obstétrique, université Paris 7 Diderot, groupe hospitalier Bichat Claude-Bernard, AP-HP, Paris, France
8 Unité de génétique clinique de La Muette, Paris, France
9 Agence de la biomédecine, La Plaine Saint Denis, France

Do in vitro fertilisation (IVF) and intrauterine insemination (IUI) induce an increased risk of congenital anomalies? This is a major question, to which most of the available epidemiological studies unfortunately seem to answer positively. However, these results are based on data obtained at birth or during the neonatal period, on small populations, and above all without taking into account the possible role of underlying female infertility, a potential confounding factor. Using the French National Health System database, we performed a comparative analysisof all singleton births in France over a five-year period (2013-2017), by natural conception (NC), embryo transfer (ET) or IVF. A total of 3,501,496 singleton births were included (3,417,089 NC, 20,218 IUI and 64,188 ET). The risks of major congenital malformations (ICD-10) were investigated according to mode of conception in multivariate analyses using multiple logistic regression models adjusted for maternal age, primiparity, obesity, smoking, history of hypertensionor diabetes and female infertility. The prevalence of malformations after ET was significantly higher than after CN, with adjusted odds ratios (aOR) of 1.15 and 1.13. The overall risk was similar in the IUI and NC groups (aOR of 1.01). An independent and overall increase in risk was observed in the presence of endometriosis (aOR of 1.16), polycystic ovary syndrome (1.20) or premature ovarian failure (1.52). This study therefore shows that causes of maternal infertility are associated with an increased risk of congenital anomalies, in addition to that associated with IVF.