John Libbey Eurotext

Magnesium Research

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Magnesium attenuates carbon tetrachloride-induced hepatic injury in rats Volume 26, issue 4, October-November-December 2013

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Authors
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran, Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran, Department of Clinical Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran

In the present study, we investigated the protective effects of magnesium sulfate (MgSO 4) against carbon tetrachloride (CCl 4)-induced liver damage in rats. MgSO 4 (0.001, 0.01, 0.05 and 0.1 Mg 2+ g/kg b.wt.) was administered intragastrically for 28 consecutive days to male, CCl 4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD) activity. Histopathological changes in the liver, of different groups were also studied. Administration of CCl 4 increased serum ALT, AST, ALP and GGT, but decreased liver SOD activities in rats. Treatment with MgSO 4 significantly attenuated these changes to nearly normal levels. The animals treated with MgSO 4 showed decreased necrotic zones and reduced hepatocellular degeneration when compared to liver exposed to CCl 4 alone. Hepatic damage was reduced in MgSO 4-treated rats. Thus, our results suggest that MgSO 4 has potential for the treatment of liver damage resulting from chemical intoxication.