MT Cardio


Physiology and physiopathology of the renin-angiotensin-aldosterone system Volume 3, issue 4, Juillet-Août 2007


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Fédération de cardiologie, CHU Henri Mondor, 52 Avenue du général de Lattre de Tassigny, 94010 Créteil, INSERM 841, Équipe 12, Faculté de Médecine, 94010 Créteil, INSERM 689 CRCIL, Hôpital Lariboisière, 41 Bd de la Chapelle 75010 Paris, Service de chirurgie cardiothoracique, 52 Avenue du général de Lattre de Tassigny, 94010 Créteil

The renin-angiotensin-aldosterone system (RAAS) plays a key role in blood pressure regulation acting primarily via the final effector of the RAAS enzymatic cascade : angiotensin II. An increasing number of studies have suggested the existence of local RAAS in several organs. The concept of RAAS paracrine-autocrine functions suggests that the locally produced angiotensin II influences tissue structure and function as vascular tone, renal hemodynamic and cardiac contractility. Most of these effects are mediated by the angiotensin II receptor AT-1. Furthermore, excessive RAAS activity is a major underlying cause of many cardiovascular diseases. Indeed RAAS inhibitors have proven to be highly successful treatments in cardiovascular disorders.