John Libbey Eurotext

Journal de Pharmacie Clinique


Comparison and practical guidelines of selective serotonin reuptake inhibitors Volume 21, issue 1, Mars 2002


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Pharmacie de l'hôpital Haut-Lévêque, avenue de Magellan, 33600 Pessac.

Depression is a recurrent and often chronic disorder, sometimes resistant. It is a major health problem. The selective serotonin reuptake inhibitors (SSRIs) are the most used products among the antidepressants. All the SSRIs have a great selectivity for serotonin reuptake, sertralin is the most powerful, citalopram the most selective; on monoamine receptors, slight differences exist. On pharmacokinetic plane, the most differences are observed on the metabolism. Except for a longer delay of action with fluoxetine vs others SSRIs, no difference was reported in the overall efficacy and tolerability. Despite a large homogeneity, practical guidelines can be overviewed.