Hôpitaux Universités Henri Mondor, Département de gastroentérologie, 51 avenue du Maréchal De Lattre De Tassigny, 94000 Créteil
Université Paris Est Créteil Val-de-Marne, Faculté de Médecine de Créteil, EA7375 EC2M3
Patients with Inflammatory Bowel Disease (IBD) experience at least one extra-intestinal manifestation (EIM) in up to 50% of the cases. EIM have a negative impact on the patient's quality of life and may interfere with treatment decision-making. EIMs are more common in CD than UC and there is a broad range of manifestations. The most prevalent EIMs in IBD are arthralgia/arthritis and skin manifestations. Most EIMs run in parallel with the intestinal disease activity but they may also have distinct course requiring multidisciplinary management. The pathogenesis of EIM in IBD is not univocal, combining a trigger immune response at the extraintestinal site due to translocation of bacterial epitopes and a shared community of genetic and environmental factors. This review focuses on the clinical features of EIM and consequences on the management of patients with IBD.
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