Hépato-Gastro & Oncologie Digestive


Liver diseases in elderly patients: a current issue Volume 22, issue 3, Mars 2015


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1 Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Equipe 8, Complications hépatiques de l’obésité, F-06204 Nice, Cedex 3, France
2 CHU de Nice, Pôle Référence Hépatite C, Hôpital de l’Archet 2, 151 Route Saint-Antoine de Ginestière BP 3079, 06202 Nice, Cedex 3, France
3 Université de Nice-Sophia-Antipolis, Faculté de Médecine, Nice, F-06107, Cedex 2, France
4 CHG de Grasse, Pôle gériatrique, Grasse, France
5 CHU de Nice, Pôle gériatrique, Nice, F-06202, Cedex 3, France
6 Université de Franche Comté, UPRES EA 4266, et Service d’hépatologie, Centre Hospitalier Universitaire de Besançon, Bld Fleming, 25000 Besançon, France
* Tirés à part

Due to aging of the general population, the proportion of patients aged more than 65 years will increase regularly. Some modifications occur in the aged liver, without significant impact in healthy people. The new direct antiviral agents should be more effective and well tolerated, allowing easy eradication of hepatitis C. However, a persistent risk of hepatocellular carcinoma persists, despite viral cure of hepatitis C, favored by cirrhosis and/or comorbidities such as a non-alcoholic steato-hepatitis. Retrospective studies suggest that the management of hepatocellular carcinoma in elderly is possible with an efficacy and tolerance similar to those observed in younger patients. Liver surgery of metastasis related to colorectal carcinoma also gives good results in elderly. All these patients requiring an aggressive treatment should be properly assessed by geriatric doctors. « Frail » people should be offered a specific help and a personalized treatment of their liver disease.