Epilepsy and memory dysfunction Volume 18, supplement 2, Numéro spécial, Septembre 2006

Laboratoire Mémoire et Cognition, Unité de Psychopathologie et de Neuropsychologie, université Paul Valéry, Montpellier 3, France, JE 2497 Neuropsychologie et Cognition Auditive, Université Charles de Gaulle Lille 3, Villeneuve d’Ascq, France, Unité d’Épilepsie, hôpital de la Salpêtrière, Paris

Among cognitive deficits reported in epileptic patients, episodic memory disorders are probably the most frequent and this is particularly true in medically intractable seizures. These disorders represent the main behavioural sign of the interictal phase because they are conditioned by abnormal electrical activities from the temporal and frontal lobes involved in episodic memory functioning. The nature of these disorders which depends on the location and the lateralization of brain dysfunction may seriously interfere with everyday life. The different memory systems (episodic, semantic, procedural and working memory or perceptual representation system) are unequally investigated in patients suffering from medically intractable seizures. However, their neuropsychological evaluation provides clinical signs that contribute to the diagnosis of epilepsy providing prognostic indications about the cognitive post surgical follow up.