John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Antiepileptic drug withdrawal in medically and surgically treated patients: a meta-analysis of seizure recurrence and systematic review of its predictors Volume 17, issue 3, September 2015

Figures

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Tables

Authors
1 Department of Child Neurology and Neurosurgery, Brain Center Rudolf Magnus
2 Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
* Correspondence: Kees P.J. Braun Department of Child Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Room KC 03.063.0, PO Box 85090, 3508 AB Utrecht, The Netherlands
  • Key words: AED withdrawal, meta-analysis, predictors, recurrence, systematic review
  • DOI : 10.1684/epd.2015.0764
  • Page(s) : 211-28
  • Published in: 2015

Aim

Many seizure-free patients consider withdrawal of antiepileptic drugs, both when seizure control is achieved by medication alone, or once they became seizure-free following epilepsy surgery. The risk of recurrence is consequently of very important prognostic value. However, estimations of recurrence risks are outdated for both populations. In addition, although many publications have reported predictors of seizure relapse, no comprehensive overview of prognostic factors is available.