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Antiepileptic drug withdrawal in medically and surgically treated patients: a meta-analysis of seizure recurrence and systematic review of its predictors Volume 17, issue 3, September 2015

TEST YOURSELF

(1) For patients with successful treatment with AEDs and seizure freedom for two years, what is the average risk of seizure recurrence after AED withdrawal?


(2) Following successful epilepsy surgery, what is the risk of seizure recurrence after AED withdrawal?


(3) Which factors independently predict seizure recurrence after AED withdrawal?

 

 

 

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Answers

(1) The risk of seizure recurrence is 22% at one year, 28% at two years, and 34% at three or four years after initiating AED withdrawal.

(2) The risk of seizure recurrence is 14% at one year, 21% at two years, 24% at three or four years, and 29% at five or more years after initiating AED withdrawal.

(3) We do not know,- current evidence is inconclusive, therefore future meta-analysis of individual participant data is necessary to answer this question.

 

 

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