John Libbey Eurotext

Epileptic Disorders


A web-based diagnostic reference centre for the European Reference Network “EpiCare”: recommendations of the eNeuropathology working group Volume 20, issue 5, October 2018

Figure 1

Flowchart of the referral procedures to be implemented in the proposed European eNeuropathology reference centre. Postsurgically, clinical centres collaborating within the European Reference Network's (ERN) Epicare program will have their surgical specimens processed for routine diagnostic work-up by their local neuropathology services; initial diagnoses (Dx) will be entered into the clinical patient management systems (CPMS). After whole-slide imaging of the relevant conventionally stained or immunohistological slides, the digitized images are uploaded via https to the open-source OMERO platform providing encrypted long-term storage and secure browser-based access to all ERN participants. The panel of ERN neuropathologists will provide consensus diagnoses, if necessary, involving additional collaborating neuropathologists. All diagnostic and morphological annotations will be synchronized with the ERN databases, CPMS, and participating hospital data management systems.

Figure 2

Case report for reference eNeuropathology using the open microscopy environment platform, OMERO.