John Libbey Eurotext

European Cytokine Network

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Undetectable levels of tumor necrosis factor‐α, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism Volume 14, issue 1, March 2003

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Authors
Laboratorio de Metabolopatías. Hospital General Universitario Gregorio Marañón, Madrid, Spain. Laboratorio de Inmuno‐Biología Molecular, Unidad de Metabolismo y Desarrollo. Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Objetive: To analyse the production of TNF‐α and NO in euthyroid and hypothyroid newborns. Patients: A cross‐sectional study was conducted involving 10 newborns diagnosed with primary congenital hypothyroidism (CH; group A) and 10 euthyroid children (group B). Results: There were undetectable plasma levels of TNF‐α and NO in the hypothyroid children, however plasma levels of TNF‐α (5.5 ± 0.5 pg\ml) and NO (5.6 ± 1.7 µM) were detected at normal levels in all euthyroid children. Moreover, expression of iNOS mRNA in PBMC, determined by RT‐PCR, was negative in both groups of infants. Conclusion: TNF‐α and NO production are both impaired in hypothyroid newborns. We report for the first time evidence of undetectable levels of TNF‐α and NO in infants with CH.