John Libbey Eurotext

European Cytokine Network


Undetectable levels of tumor necrosis factor-alpha, nitric oxide and inadequate expression of inducible nitric oxide synthase in congenital hypothyroidism Volume 14, issue 1, March 2003


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Hospital General Universitario Gregorio Marañón, Servicio de Inmunología, C/Dr. Esquerdo 46, 28007 Madrid, Spain.

Objetive: To analyse the production of TNF-alpha and NO in euthyroid and hypothyroid newborns. Patients: A cross-sectional study was conducted involving 10 newborns diagnosed with primary congenital hypothyroidism (CH; group A) and 10 euthyroid children (group B). Results: There were undetectable plasma levels of TNF-alpha and NO in the hypothyroid children, however plasma levels of TNF-alpha (5.5 ± 0.5 pg/ml) and NO (5.6 ± 1.7 muM) were detected at normal levels in all euthyroid children. Moreover, expression of iNOS mRNA in PBMC, determined by RT-PCR, was negative in both groups of infants. Conclusion: TNF-alpha and NO production are both impaired in hypothyroid newborns. We report for the first time evidence of undetectable levels of TNF-alpha and NO in infants with CH.