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Metabolic link between obesity and autoimmune diseases Volume 32, issue 4, December 2021

Figures


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Authors
1 Dept. Environmental Medicine, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
2 Institute of Human Genetics, Polish Academy of Science, Strzeszynska 32, 60-479 Poznan, Poland
3 Dept. Hypertension, Angiology and Internal Medicine, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
4 Dept. Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Fredry 10, 61-701 Poznan, Poland
* Correspondence

The abnormal accumulation of visceral adipose tissue in obesity is associated with metabolic changes that include altered glucose tolerance, insulin resistance, hyperlipidemia, and metabolic syndrome. Obesity also coincides with increased incidence of autoimmune diseases. Accumulating evidence suggest that prolonged metabolic overload related to overnutrition, influenced by genetic and epigenetic factors, might affect immunologic self-tolerance through changes in the energy metabolism of immune cells, particularly regulatory T (Treg) cells. A strong activation of nutrient-energy signaling pathways blocks the induction of the transcription factor forkhead P3 (FOXP3), a master regulator of Treg cells, consequently inhibiting their generation and proliferation, thereby promoting proinflammatory response. Expanding our knowledge on the topic, particularly on metabolic T cell flexibility in vivo will provide new insights that can be used to develop therapeutic strategies for various inflammatory diseases, including obesity and autoimmune diseases. Targeting specific metabolic pathways is emerging as an important approach to control immune response and maintain immunological homeostasis.