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Target on molecular therapies in lung cancer Volume 90, issue 12, Décembre 2003

Authors
Département de médecine, Institut Gustave‐Roussy, 39, rue Camille‐Desmoulins, 94805 Villejuif Laboratoire de radiobiologie et oncologie, CEA, DSV\DRR, 10, route du Panorama, 92265 Fontenay‐aux‐Roses

Molecular targeted therapies offer great hope in lung cancer because they are supposed to act upon biologic abnormalities specific to cancer cells. In the present review, we will describe the major pathways of tumor cell growth, apoptosis, angiogenesis and invasion as well as the targeted therapies interacting with these pathways. We will provide an overview of the trials involving targeted therapies in lung cancer, along with the specific problems related to the development of these new therapies. ▴