John Libbey Eurotext

Bulletin du Cancer


Dose individualisation for carboplatin in cancer chemotherapy Volume 84, issue 6, Juin 1997

Service d’oncologie médicale, Hôpital Hôtel-Dieu de Paris, 1, place du Parvis-Notre-Dame, 75181 Paris Cedex 04, France.

The aim of optimizing drug therapy for an individual patient is to maximize the likelihood of a desired therapeutic effect and to minimize the likelihood of toxicity. The excellent correlations between renal function and carboplatin total body clearance and between carboplatin area under the plasma concentration by time curve and thrombocytoprenia allow calculation by Chatelut formula of carboplatin dosage.