JLE

Bulletin du Cancer

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Hypoxia, HIF1α and estrogen receptor Volume 91, issue 9, Septembre 2004

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Université René-Descartes, U-490 Inserm, 45 rue des Saints-Pères, 75270 Paris Cedex

The estrogen receptor plays an important role in the development of hormone-dependent breast cancer. Experimental and clinical studies showed that hypoxia was involved in tumor progression and in the resistance to anticancer agents. The scope of this review is to summarize recent observations on these two signaling pathways and to show their importance and possible interaction in the development of hormone-dependent breast cancer.