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Annales de Gérontologie

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Early cognitive disorders in parkinson’s disease in function of age with the FAB scale Volume 2, issue 2, avril 2009

Authors
Neurologue, Service de Gériatrie, Hôpital Bretonneau, Paris, Psychologue, Service de Gériatrie, Hôpital Bretonneau, Paris, Chef de Service de Gériatrie, Hôpital Bretonneau, Paris, Chef de Service de Psycho-Gériatrie, Hôpital Bretonneau, Paris

Early cognitive changes in patients with Parkinson’s disease are often subtle and influenced by factors that interact with the disease process, including age of disease onset. Executive function deficits are the most frequently reported cognitive problems. The aims of this study was to determine the frequency and pattern of cognitive dysfunction in patients with newly diagnosed Parkinson’s disease in function of age of disease onset and the importance of the FAB scale. A cohort of 56 consecutive patients with newly diagnosed Parkinson’s disease underwent a detailed clinical evaluation with included assessments of Parkinsonians signs and cognitive status. Three groups were compared : < 75 years old (group 1, 23 patients), ≥ 75 years (group 2, 33 patients) and witness ≥ 75 years (group 3, 30 patients) without extrapyramidal syndrome or cognitive impairment. In the first group, subjects show more MMS and FAB low score in comparison of group 2 patients, while memory complaints were comparable. Group 3 shows only differences with the FAB score in comparison of the first group. This abnormal executive function assess with de FAB were important for take care old subjects with Parkinson disease in drug administration and help at home. These cognitive abnormalities should be explain the greater risk of dementia in these subjects.