Annales de Biologie Clinique


Comparison of blood gas results obtained on Abbott i-Stat® and on Radiometer ABL 800 Flex® analyzers Impact for the clinical decision Volume 80, issue 6, November-December 2022


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1 Intensive Care Unit, Ambroise-Paré Hospital, Assistance Publique Hôpitaux Paris and Paris Saclay University, Boulogne Billancourt, France
2 Centre de recherche en épidémiologie et santé des populations, Inserm U1018, Paris Saclay University, France
3 Institut de recherche biomédicale et d’épidémiologie du sport, EA7329, INSEP, Paris University, France
4 Department of clinical biochemistry, Necker Hospital, AP-HP, Paris, France
Correspondance : JL Beaudeux


Point of care testing (POCT) tests are needed to assess severity and to help for triage in hospital and in prehospital settings. Before their use, the analytical performances of POCTs have to be compared with central laboratory reference methods. In this study, we describe the comparability of results obtained by either the Abbott i-STAT® System POCT handheld device or the blood gases analyzer of the central laboratory of our hospital.


Sample blood from 37 septic patients admitted to the intensive care unit (ICU) were assayed by Abbott i-STAT® System POCT and Radiometer ABL800 Flex® lab analyzer. Studied parameters were as follows: pH, pO2, pCO2, base excess (BE), HCO3 and lactate. Comparability was evaluated using Bland-Altman method. The clinical value for possible mismatch issued of values differences was also assessed.


Quite acceptable correlations in results of POCT and laboratory analyzer were observed with R2 most of time above 0.85. Bland-Altman analysis showed a bias of 1.26% for Abbott i-STAT® System POCT vs laboratory.


Abbott i-STAT® System POCT handheld device is comparable to Radiometer ABL800 Flex® lab analyzer and concordant with laboratory analysis. Abbott i-STAT® System POCT handled device could be used in the prehospital settings in order to evaluate the severity of sepsis.