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Revue de neuropsychologie

Semantic dementia: demography and neuropsychological assessment in a cohort of 82 cases Volume 3, numéro 4, Décembre 2011

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  • Auteur(s) : Serge Belliard, Catherine Merck, Pierre Yves Jonin, Sandrine Lemoal, Martine Vercelletto , Centre mémoire de ressource et de recherche, Service de neurologie, CHU Pontchaillou, rue Henri Le Guilloux, 35033 Rennes Cedex, Inserm- EPHE-Université de Caen/Basse Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, Consultation mémoire, Centre Hospitalier de Guingamp, Centre mémoire de ressource et de recherche, service de neurologie, Hôpital Nord, Nantes 44093
  • Mots-clés : semantic dementia, semantic memory, frontotemporal dementia
  • Page(s) : 257-65
  • DOI : 10.1684/nrp.2011.0195
  • Année de parution : 2011

Semantic Dementia (SD) is a subject of a rich literature, but few large series are available. We report the demographics and neuropsychological data of a cohort of 82 patients followed prospectively for 20 years. Semantic Dementia begins before age 65 in 75 % of cases, but we have hold this diagnosis in two subjects over 80 years. In accordance with the classification of the French consensus of 2008, initially 71 % of patients could be classified as typical SD with an isolated, multimodal semantic memory impairment. 11 % could be classified as atypical SD due to pure verbal semantic impairment and 18 % as atypical SD because of the existence of discrete extralinguistic disorders (type 2). Two years later, 28.5 % of typical SD exhibited extralinguistic disturbances and all initial pure verbal SD exhibited multimodal semantic memory impairment. Although classified as a subtype of progressive aphasia, SD is more than a semantic verbal deficit in the vast majority of cases.