John Libbey Eurotext

Hématologie

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Blastic morphology of a hepatosplenic T cell lymphoma in a patient treated by immunosuppressive drugs for ulcerative colitis Volume 26, issue 1, Janvier-Février 2020

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Authors
1 Laboratoire de biologie clinique, secteur hématologie, Grand Hôpital de Charleroi, Charleroi, Belgique
2 Centre d’anatomopathologie, Institut de pathologie et de génétique, Charleroi (Gosselies), Belgique
3 Service d’oncohématologie, Grand Hôpital de Charleroi, Charleroi, Belgique
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We hereby report a case of a hepatosplenic T-cell lymphoma and highlight the importance of considering this diagnosis. Our patient was receiving a long-term immunosuppressive treatment and presented cytopenias, B-symptoms, no lymphadenopathy and non-specific clinical characteristics. When cytopenias are discovered in a patient under an immunosuppressive treatment for a digestive auto-immune disease, a bone marrow aspiration and biopsy are required and a diagnosis of hepatosplenic T-cell lymphoma must be considered. Despite a large variability in morphology, the clinical presentation, the immunophenotype and the sinusoidal distribution of the cells allow the diagnosis to be established.

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