European Journal of Dermatology


The use of genetically engineered mice in immunodermatology Volume 7, issue 4, June 1997

Unité de Biologie Moléculaire du Gène, Unité INSERM U. 277, Département d’Immunologie, Institut Pasteur, 25, rue du Dr-Roux, 75015 Paris, France.

The modern techniques of genetics have permitted the creation of animals in which distinctive genes are either selectively destroyed (KO mice) or expressed under abnormal conditions (transgenic animals). The use of such engineered animals for the study of skin diseases is discussed.