European Journal of Dermatology


The use of genetically engineered mice in immunodermatology Volume 7, numéro 4, June 1997

Unité de Biologie Moléculaire du Gène, Unité INSERM U. 277, Département d’Immunologie, Institut Pasteur, 25, rue du Dr-Roux, 75015 Paris, France.
  • Page(s) : 247-50
  • Année de parution : 2000

For a long time, only a few spontaneous mutants and distinctive polymorphisms of the many mouse strains have significantly contributed to the understanding of the cellular and molecular mechanisms which underlie the functioning of the immune system. Some of these mutants are actually used as model systems for human diseases such as systemic lupus (lpr and gld mutants) or diabetes (NOD mice). In the last 10 years, the alteration, [...]