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Cell biology of phlebovirus entry Volume 23, issue 3, Mai-Juin 2019

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Authors
1 University Hospital Heidelberg,
CellNetworks – Cluster of Excellence and Department of Infectious Diseases,
Virology,
Im Neuenheimer Feld 344,
69120 Heidelberg,
Allemagne
2 Fundación Ciencia & Vida,
Molecular Virology Laboratory,
Av. Zañartu 1482,
7780272 Santiago,
Chile
3 IVPC UMR754, INRA,
Université Claude-Bernard-Lyon 1,
EPHE, 50, avenue Tony-Garnier,
69007 Lyon, France
* Correspondance
a Ces auteurs ont contribué à ce travail de façon équivalente.

Phleboviruses constitute a large group of arthropod-borne viruses (arboviruses), mainly transmitted to their hosts by sandflies and ticks, occasionally by mosquitoes. These viruses have a worldwide distribution and many cause serious diseases – often fatal – in both domestic animals and humans. The global warming, the apparent wide distribution of arthropod reservoirs, and the increasing number of outbreaks show that phleboviruses must be taken seriously as emerging disease agents. This review proposes to focus on the early steps of phlebovirus infection, from virus binding to penetration into the cytosol. We address the most recent knowledge and advances in the entry of these viruses into vertebrate host cells, including virus receptors, cellular factors, endocytic pathways, and fusion.

Licence This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License