- Page(s) : 80-8
- Published in: 1998
Decreased albumin concentration in plasma is associated with dyslipidemia. This pathophysiology has mostly been studied in nephrotic syndrome and congenital analbuminemia. Since it was recently shown that this dyslipidemia is atherogenic, it is of major importance to understand its pathophysiology better in order to design efficient treatment. This dyslipidemia is secondary to both an increase in the synthesis and a decrease in the catabolism of very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and low density lipoprotein (LDL). Furthermore, decreased plasma albumin concentration is associated with a redistribution of plasma free fatty acids towards the lipoprotein fractions, modifying their biophysical properties, which in turn upregulates the cholesteryltrans fer protein (CETP) activity. Therefore, increased CETP activity could be an important feature of dyslipidemia secondary to hypoal-buminemia.