Néphrologie & Thérapeutique


Limited sampling strategy for the estimation of mycophenolic acid area under the curve in Tunisian renal transplant patients Volume 13, issue 6, 2017-11-01


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1 IntroductionMycophenolate mofetil is a prodrug widely used in renal transplantation to prevent organ rejection. It is hydrolyzed to its active compound mycophenolic acid (MPA). MPA acts by inhibition of inosine monophosphate dehydrogenase (IMPDH) which is involved in DNA synthesis. Its pharmacokinetics in transplant recipients is characterized by alarge variability in different parameters including the area under the plasma concentration curve (AUC), trough plasma concentration (C0), maximal plasma [...]