Néphrologie & Thérapeutique


Interest of therapeutic drug monitoring of aminoglycosides administered by a monodose regimen Volume 15, issue 2, Avril 2019


  • Fig. 1

  • Fig. 2


  • Table 1

  • Table 2

  • Table 3

1 IntroductionAminoglycosides (AG) have been widely used in clinical practice since 1940s [1]. They are characterized by broad-spectrum antimicrobials that make them effective in the treatment of serious infections caused by Gram-negative bacteria such as Pseudomonas aeruginosa [2].These antibiotics are characterized by a narrow therapeutic index and a large within and between variability in pharmacokinetics. This variability among individuals has been attributed to several factors, such as variation [...]