Médecine Thérapeutique / médecine de la reproduction


PPAR γ ligands and the control of metabolism Volume 7, issue 2, Mars-Avril 2005


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Equipe Avenir Inserm U540, 60 rue de Navacelles, 34090 Montpellier, Laboratoire de Biologie cellulaire, CHU Montpellier, 34090 Montpellier

Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the hormone nuclear receptor superfamily. It has been largely demonstrated that PPARγ plays a key role in adipocyte differentiation and is a master controller of the energy balance. PPARγ is activated by naturally occuring ligands such as prostaglandin J2 derivatives, and by synthetic ligands such as thiazolidinediones. PPARγ ligands are potent insulin sensitizing drugs used to treat type 2 diabetes mellitus. More recently PPARγ emerged from a role limited to metabolism (diabetes and obesity) to a powerplayer in general transcriptional control of numerous cellular processes, including cell cycle control, carcinogenesis, inflammation, atherosclerosis, and immunomodulation. We discuss in this review the role of PPARγ ligands in insulin sensitization as well as the possible applications in other pathologies.