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Médecine de la Reproduction

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Proteomics of the endometrium and associated pathologies Volume 14, issue 4, Octobre-Novembre-Décembre 2012

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Authors
Fundacion IVI-INCLIVA. C/ Catedrático Agustín Escardino 9, (Paterna) Valencia, Spain. 46980, IVI Barcelona, Barcelona, Spain Ronda General Mitre 14, 08017, Barcelona, Hospital LaFE, Bulevar Sur s/n, Valencia, Spain. 46026

Recently, major advances in the genomics of the endometrium and oocytes have been achieved with the microarray and bioinformatics technologies available to provide a vast amount of information regarding the gene expression. However, the gene expression is only one aspect of the complex regulatory network that allows cells to respond to intracellular and extracellular signals. Unlike the genome, the proteome itself is dynamic, complex and variable, and it depends on the developmental stage of the cells reflecting the impact of both internal and external environmental stimuli. Proteomics is often considered the next step in the study of biological systems, and is more complicated than genomics, mostly because the proteome differs from cell to cell while an organism's genome is constant. Up to date, lack of sensitivity is still a stumbling block for the global introduction of proteomics into the field of human reproduction. However, new developments in mass spectrometry using protein profiling and peptide sequencing have been implemented to elucidate the underlying biological processes. In this chapter, we will review the state of the art of proteomics focusing on the endometrium and associated pathologies.