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Médecine de la Reproduction

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Pregnancy and breast cancer Volume 16, issue 3, Juillet-Août-Septembre 2014

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Authors
Hôpital Tenon, AP-HP, 4, rue de la Chine, 75020, Paris, France
* Tirés à part

The occurrence of pregnancy-associated breast cancer (PABC) is rare. Its management is a challenge: to treat the patient without compromising fetal prognosis. Usually, PABC is diagnosed at a more advanced stage compared to non-pregnant patients of the same age. The diagnostic approach should fit with the recommendations for non-pregnant women except CT scan or isotopic exploration which are not indicated. Similarly, the therapeutic management should be close to guidelines: surgical treatment and sentinel lymph node procedure (without patent blue), chemotherapy beyond the first trimester and radiotherapy – to discuss- during the 1st and 2nd trimesters (most of the time delayed to the post partum). Targeted therapy and hormonal therapy are not recommended during pregnancy. After this treatment, the prognosis of PABC is comparable to non-pregnant patients with similar clinical, histological and radiological characteristics.