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Circulating MicroRNAs and folliculogenesis: New approch for understanding dialog between follicular cells Volume 21, issue 2, Avril-Mai-Juin 2019

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Authors
1 Centre AMP Avignon, laboratoire Bioaxiome, Avignon, France
2 Université Grenoble-Alpes, Inserm 1036, Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Institut de Biosciences et Biotechnologies de Grenoble (BIG), Laboratoire biologie du cancer et de l’infection (BCI), Grenoble, France
3 Centre hospitalier universitaire de Grenoble, hôpital Couple-Enfant, centre clinique et biologique d’assistance médicale à la procréation, Centre d’étude et de conservation des œufs et du sperme humains (Cecos), La Tronche, France
4 Inserm U1203, Équipe Développement embryonnaire précoce humain et pluripotence, Institut de médecine régénératrice et de biothérapie, Hôpital Saint-Eloi, Montpellier 34295, France
5 CHU Montpellier, ART/PGD Division, Hôpital Arnaud de Villeneuve, Montpellier, France
* Tirés à part

The good progress of the folliculogenesis is fundamental for obtaining an oocyte capable of generating an embryo having a good implanting potential. During this follicular development, the oocyte has a special relationship with the cumulus cells surrounding it and with which it forms a cumulo-oocyte complex. A dialogue is thus established inside the follicle, thanks to communicating junctions and paracrine signals allowing the oocyte to control certain functions of the cumulus cells in order to ensure its own survival. This interaction is expressed by the expression of key genes, which are themselves regulated by short RNA fragments, about 19-25 nucleotides, called microRNAs. The identification of microRNAs involved in the intrafollicular dialogue should lead to obtaining non-invasive tests to assess the oocyte quality.

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