John Libbey Eurotext

Médecine de la Reproduction

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Spheroids and oviduct organoids: new models to better understand fertility Volume 24, issue 2, Avril-Mai-Juin 2022

Figures

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Authors
Equipe interactions cellulaires et fertilité, UMR Inrae, CNRS, université de Tours, IFCE, Nouzilly, France <karine.reynaud@inrae.fr>
* Tirés à part : K. Reynaud

Spheroids and organoids are cellular models capable of selforganisation in 3 dimensions in vitro and which mimic the organisation of an organ. The oviduct, located between the ovary and the uterus, is the site of final gamete maturation, fertilisation and early embryonic development. Our objective is to develop oviduct spheroids and organoids to better understand the roles of this organ in the mechanisms of sperm storage and selection by the maternal organism, as well as in the embryo-maternal dialogue during the development of the young embryo.