Médecine de la Reproduction


Male causes of blastulation alterations Volume 26, issue 1, janvier-février-mars 2024


  • Figure 1.
UF spermiologie diagnostique, service AMP-Cecos, CHU Clermont-Ferrand, France ; UMR université Clermont Auvergne- INSERM- U1240- Imagerie moléculaire et stratégies théranostiques IMoST, Clermont-Ferrand, France
* Tirés à part : H. Pons-Rejraji

Beyond providing half of the genetic information, a functionally motile and morphologically typical spermatozoon is essential for a successful fertilization and achievement of the embryo development. It is now well demonstrated that sperm alterations may cause dysfunctions in upstream embryonic development and blastulation rate even independently of paternal genome activation. Indeed, the sperm proteome, transcriptome, genome and epigenome are essential for the stages of sperm-pellucid zone recognition, fertilization, but also embryonic development up to the blastocyst stage. Thus, one can distinguish paternal effects on fertilization, early stages (J1-J2) taking place before the paternal genome activation, and finally late stages (from J3) of embryonic development. These different elements will influence the rate of zygotes, cleaved embryos and blastocysts obtention but also the embryogenesis morphokinetics and the blastocysts’ quality.