Médecine de la Reproduction


Proteomics in endometriosis : a systematic review Volume 14, issue 4, Octobre-Novembre-Décembre 2012

Service Chirurgie Gynécologique, CHU Estaing, 1, Place Lucie et Raymond Aubrac, 63003 Clermont Ferrand Cedex 1

Although the definition of endometriosis is very well defined : presence of endometrial-like tissue outside the uterus, leading to a chronic inflammatory condition, the physiopathology of the disease is still uncertain. Proteomics is one of the future ways to explore this physiopathology and new therapeutic approaches. Published studies on proteomics in endometriosis have been performed using serum, ectopic or eutopic endometrial tissue from patients with and without endometriosis. With new techniques (including protein arrays) new hopes have raised although most of the studies have used classical techniques. No matter is the used technic, published papers showed « surprising » and little reproducible results. They should allow the discovery of new hypotheses in physiopathology and treatment of the disease (for example the unsuspected role of haptoglobin, brain-derived neurotrophic factor or proteins involved in the regulation of the cell cycle). The number of team working on proteomics in endometriosis is constantly rising and there is hope for major discoveries in terms of diagnosis (biomakers) and treatment (targeted therapies).