JLE

Hépato-Gastro & Oncologie Digestive

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Cholestasis Volume 20, issue 8, Octobre 2013

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Author
Hôpital Beaujon, service d’hépatologie ; Université Paris-Diderot et Inserm U773, 92118 Clichy-la-Garenne, France

Blood tests that contribute to the diagnosis of cholestasis are limited to the determination of alkaline phosphatase, gamma-glutamyl transpeptidase activity, and conjugated and unconjugated bilirubin. Certain clinical features have a high specificity but their sensibility is poor. Biliary imaging, liver biopsy and occasionally molecular genetic testing may be needed. Cholestasis related to an acquired dysfunction in biliary transport systems has been underestimated. Cholestatic jaundice is generally multifactorial in origin.