John Libbey Eurotext

Hématologie

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Haemoglobin and haemoglobinopathies at the forefront of the 21st century Ahead of print

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Author
Inserm U955, IMRB hôpital Henri Mondor, Créteil
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This review aims to take stock of recent advances and perspectives in various fields (physiology, physiopathology, and therapy) related to haemoglobin and haemoglobin disorders. This includes gaseous signalling molecules (NO, CO, H2S), blood flow changes in microcirculatory units, metabolic regulation of red blood cells and other systems, the regulatory stages that determine the expression and intracellular concentration of a model protein, control of differentiation and cell mass of tissues or organs, gene switching during development and its therapeutic reversion, comprehensive care of patients with sickle cell disease or β-thalassaemia, targeted therapies, allo-transplantation, and gene therapy (gene addition or gene editing).