Electric source imaging in partial epilepsies presurgical assessment. Volume 16, issue 4, Octobre-Novembre-Décembre 2004


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Laboratoire de neurophysiologie et neuropsychologie, Inserm E 9926, faculté de Médecine, 27 bd Jean Moulin, Marseille, Service de Neurophysiologie clinique, hôpital de la Timone, 264 rue Saint-Pierre, Marseille

Techniques of recording of cerebral electromagnetic activities can be combined with algorithms that permit resolution of the inverse problem, thus making it possible to increase their spatial resolution (EEG-HR or EEG High Resolution and MEG: magnetoencephalography, in which cerebral magnetic activity is recorded). In epileptic patients, interictal electromagnetic spikes can be recorded on surface EEG or MEG and, if they are reliably localised in anatomical space, can help to determine the cerebral area that generates them (irritative zone). These new techniques are currently in constant evolution and are being used by a growing number of teams. Some of these teams have described a level of precision of source localization described as “sub-lobar” but validation of these data are often carried out in a very heterogeneous way. In this paper, we will first introduced the methods including its technical aspects, explaining each step of an HR-EEG. Secondly we will present a review of the literature and of our own data, concerning interictal spikes source localization in temporal lobe epilepsies and in frontal lobe epilepsies. This work was carried out partly thanks to a grant from LFCE, Sanofi-Synthelabo 2002.