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Epilepsies

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Histological and electrophysiological characterization of the kaïnate model for the mesial temporal lobe epilepsy in different strains of mice. Volume 18, issue 2, Avril-Mai-Juin 2006

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Authors
Laboratoire de Neurobiologie, Equipe Génétique des Epilepsies, Université d’Orléans, France, adresse actuelle : UMR-INRA SENAH, Equipe AlimH, Rennes, France, UMR U704 INSERM-UJF, Dynamique des réseaux neuronaux, Université Joseph Fourier, Grenoble, France

The mesial temporal lobe epilepsy (MTLE) is characterized by hippocampal seizures and hippocampal sclerosis associated with a dispersion of the dentate gyrus granule cells in most of the patients. The mechanisms underlying these histological changes remain unknown. Recently, a mouse model for MTLE has been developed in which an intrahippocampal injection of kaïnic acid (KA) induces, two weeks after, hippocampal recurrent seizures and hippocampal sclerosis associated with granule cells dispersion of the dentate gyrus (DG). In this study, we have compared the epileptogenesis development and the neuroanatomical variations (neuronal loss, DG dispersion) between several strains of mice after an intrahippocampal injection of KA. Our results show a large variety of reactivity and a high toxicity for some lines. Statistical difference for epileptogenesis was observed between three mouse strains (C57BL/6J, CBA/H et DBA/2J) without showing any differences for the granule cell dispersion and neuronal loss in the Ammon’s horn. These data suggest a genetic componant in epileptogenesis which is not linked to the histogical changes of hippocampus.