John Libbey Eurotext

Research perspectives in cortical dysplasia and associated epilepsies Volume 1, issue 4, Décembre 1999

Division of Experimental Neurophysiology and Epileptology,Istituto Nazionale Neurologico “C.-Besta”, Via Celoria, 11, 20133 Milano, Italy

Our understanding of cortical alterations and related epilepsies has grown enormously in the last decade thanks to the explosion of basic information from laboratory neuroscience combined with advances in diagnostic tools, therapeutic approaches and surgical techniques. In the present paper, we briefly review the most important advances in these fields from the point of view of the clinician concerned with cortical malformation-related epilepsies. We propose that a highly effective way forward, expected not only to widen knowledge of the basic mechanisms of seizure generation, but also to improved the management of patients, would be to promote interdisciplinary research programmes on resected human cortex that involve neurosurgeons, neurologists and laboratory neuroscientists.