Epileptic Disorders


Rational conversion from antiepileptic polytherapy to monotherapy Volume 5, issue 3, September 2003

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23. Beydoun A. Monotherapy trials of new antiepileptic drugs. Epilepsia 1997; 38 (suppl 9): S21-31.

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28. Sachdeo R, Beydoun A, Schachter S, et al. Oxcarbazepine (Trileptal) as monotherapy in patients with partial seizures. Neurology 2001; 57: 864-71.

29. Beydoun A, Sachdeo RC, Rosenfeld WE, et al. Oxcarbazepine monotherapy for partial-onset seizures: a multicenter, double-blind, clinical trial. Neurology 2000; 54: 2245-51.

30. Sachdeo RC, Reife RA, Lim P, et al. Topiramate monotherapy for partial-onset seizures. Epilepsia 1997; 38: 294-300.

31. Beydoun A, Fischer J, Labar DR, et al. Gabapentin monotherapy: II. A 26-week, double-blind, dose-controlled, multicenter study of conversion from polytherapy in outpatients with refractory complex partial or secondary generalized seizures. The US Gabapentin Study Group 82/83. Neurology 1997; 49: 746-52.

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33. Beydoun A, Kutluay E. Conversion to monotherapy: clinical trials in patients with refractory partial seizures. Neurology 2003; 60 (11 Suppl 4): S13-25.

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35. Deckers CLP. Overtreatment in adults with epilepsy. Epilepsy Res 2002; 52: 43-52.

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38. Perucca E, Levy R Combination therapy and drug interactions. In: Antiepileptic drugs. 5th edition, Levy R, Mattson R, Meldrum B, Perucca eds, 2002, Lippincott Williams and Wilkin pp. 96-102.

39. Brodie MJ, Yuen AWC and the 105 Study Group. Lamotrigine substitution study: evidence for synergism with sodium valproate ? Epilepsy Res 1997; 26: 423-32.

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41. Anderson G, Gidal B, Messenheimer J, et al. Time course of lamotrigine de-induction: impact of step-wise withdrawal of carbamazepine or phenytoin. Epilepsy Res 2002; 49: 211-7.

42. Sachdeo RC, Sachdeo SK, Levy RH, et al. Topiramate and phenytoin pharmacokinetics during repetitive monotherapy and combination therapy to epileptic patients. Epilepsia 2002; 43: 691-6.


Seizure type

Level of evidence

Side effect