Figure 1
Progression of electroencephalographic (EEG) changes in a patient with Lafora disease. (A) At the time of disease onset (age 17 years), normal to slightly slowed background activity. (B) Two years later (age 19 years) EEG demonstrates asymmetric generalized spikes and polyspikes, maximum over the anterior regions on a slowed background. (C) At age 20 years, the occurrence of fast (4-6 cycles per second) spike-waves was concomitant with head drops. During the final stages of the disease, EEG recordings show long bursts of diffuse spike-waves and fast polyspikes associated with major volleys or massive myoclonic jerks (D), dramatically enhanced by photic stimulation at low frequency (E). Modified from Striano et al., 2008.