John Libbey Eurotext

Generalized periodic discharges with triphasic morphology: to treat or not to treat? Volume 23, issue 2, April 2021


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Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
* Correspondence: Fábio Augusto Nascimento e Silva 55 Fruit St., Wang 7th floor, Boston, MA, USA. 02114

We report an 82-year-old woman with recurring episodes of confusion, a left posterior fossa meningioma, and chronic hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH). She presented with a habitual episode of confusion. Basic laboratory workup was unremarkable except for hyponatremia (132 mEq/L sodium); head imaging was unrevealing. Continuous EEG showed 2-Hz generalized periodic discharges (GPDs) with triphasic morphology, or “triphasic waves” (figure [...]

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