John Libbey Eurotext

Clinical evolution and epilepsy outcome in three patients with CDKL5-related developmental encephalopathy Volume 21, issue 3, June 2019


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1 Department of Paediatric Neurosciences, Santobono-Pausilipon Children's Hospital, Naples
2 Department of Translational Medical Sciences, Child and Adolescent Neuropsychiatry, University of Naples Federico II, Naples
3 NESMOS Department, Sant’ Andrea Hospital, “Sapienza” University of Rome, Rome
4 Regional Referral Centre for Neurofibromatosis, Department of Woman, Child, General and Specialistic Surgery, “Luigi Vanvitelli” University of Naples, Naples
5 Department of Neuroscience, Reproductive and Odontostomatological Sciences, Epilepsy Centre, Federico II University, Naples
6 Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto “G. Gaslini”, Genova
7 Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy
* Correspondence: Pia Bernardo Department of Paediatric Neurosciences, Neuropsychiatry Unit, Santobono-Pausilipon Children's Hospital, Via Mario Fiore n.6, 80129, Naples, Italy


To further characterise CDKL5-related disorder, previously classified as an early-onset seizure variant of Rett syndrome, which is currently considered a specific and independent early-infantile epileptic encephalopathy.