Epileptic Disorders


Adding topiramate to valproate therapy may cause reversible hepatic failure Volume 5, issue 3, September 2003

Neurosciences Department University Hospital of Luxemboug Epileptology Department, University of Bonn, Germany

The authors report a 51‐year‐old women with pharmacoresistant partial epilepsy who tolerated well valproate monotherapy and in combination with several other antiepileptic drugs, but developed symptoms and signs of reversible hepatic failure under a combination of valproate and topiramate. Symptoms resolved after discontinuation of VPA. This case provides further anecdotal evidence that topiramate may increase the risk of liver failure when given in combination with other potentially hepatotoxic antiepileptic drugs.