John Libbey Eurotext

European Journal of Dermatology


The relationship between aquaporins and skin diseases Volume 33, issue 4, July-August 2023


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1 Department of Laboratory Medicine,Jilin Medical University, 132013, Jilin City, Jilin Province, China
2 Department of Dermatology, Yanbian University Hospital, Yanji City, Jilin Province, 133000, China
3 Department of public health,Jilin Medical University, 132013, Jilin City, Jilin Province, China
4 Department of Basic Medicine, Jilin Medical University. 132013, Jilin City, Jilin Province, China
* Reprints: Yong Jiang, Yuji Jin
# These authors contributed equally

Aquaporins (AQPs) are a family of transmembrane channel proteins that can rapidly transport water molecules. The main subtype expressed in the epidermis and dermis is AQP3. Studies have confirmed that AQPs exert certain physiological functions in the skin, such as the maintenance of normal shape, the regulation of body temperature, moisturization and hydration, anti-aging, damage repair and antigen presentation. The abnormal expression of AQPs in skin cells can lead to a variety of skin diseases. This review summarizes the relevance of AQPs in dermatophysiological and pathophysiological processes, highlighting their potential as new drug targets for the treatment of skin diseases.

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