John Libbey Eurotext

European Journal of Dermatology


Stiff skin syndrome: a clinicopathological study of 31 cases Volume 33, issue 3, May-June 2023


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1 Department of Dermatology, Xijing Hospital, the Fourth Military Medical University, No.127 of Changlexi Road, Xian 710032, China
2 Department of Dermatology, Zigong Fourth People’s Hospital, Zigong, Sichuan, China
* Reprints: Lei Wang

Stiff skin syndrome (SSS) was first described by Esterly and McKusick in 1971 [1]. It usually presents as progressive fibrosis of the skin at birth or in early childhood, which may cause joint immobility in the following years. In 2016, Myers et al. [2] divided SSS into segmental and widespread SSS according to the distribution of the lesion, age at onset and functional limitation. According to the literature [3–9], about 71 cases of SSS have been reported, including 30 segmental SSS and 41 widespread [...]