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European Journal of Dermatology

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Epidemiology and characteristics of acral lentiginous melanoma compared to lentigo melanoma in France: a multicentric retrospective study from the French cohort RIC-Mel database Volume 32, issue 6, November-December 2022

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Authors
RIC-Mel NETWORK
1 Dermatology Unit, Caen-Normandie University Hospital, Caen, France
2 Dermatology Unit, Nantes University Hospital, Nantes, France
3 Dermatology Unit, Cancer Research Center of Lyon, Lyon University Hospital, Claude Bernard University, Lyon, France
4 Dermatology Unit, Rennes Hospital, Rennes, France
5 Dermatology Unit, Nice Hospital, Nice, France
6 Dermatology Unit, Montpellier University Hospital, 34295 Montpellier, France
7 ONCO-THAI, INSERM Unit 1189, Lille University Hospital, Lille, France
8 Dermatology Unit, Grenoble Hospital, Grenoble, France
9 Dermatology Unit, La Rochelle Hospital, La Rochelle, France
10 Dermatology Unit, Valence Hospital, Valence, France
11 Dermatology Unit, Toulouse III University - Paul Sabatier, Toulouse University Hospital, France
12 Dermatology Unit, Avicennes Hospital, AP-HP, Paris, France
13 Dermatology Unit, Hospices Civils de Lyon, Lyon 1 University, Lyon, France
14 Dermatology Unit, Dijon Hospital, Dijon, France
15 Dermatology Unit, Bordeaux Saint-Andre Hospital, Bordeaux, France
Reprints: Jean-Matthieu L’Orphelin

Background

Skin phototype, latitude and sun exposure are classic risk factors for melanomas but are not relevant to acrolentiginous melanomas (ALM). ALM is not related to chronic sun exposure because the thick stratum corneum acts as a barrier to penetration of UV rays, whereas LMM occurs in skin with high photoaging due to chronic sun exposure.

Objectives

This study aimed to determine if any difference exists between “solar” melanomas and “non-solar” melanomas based on a comparison between LMM and ALM.

Materials & Methods

We extracted all data for ALM and LMM patients, from March 2012 to September 2020, from the RIC-Mel national database to perform a descriptive cohort analysis of 1,056 Caucasian cases.

Conclusion

The profiles of solar-related and non-solar melanoma seem to be different, and prognostic factors of ALM at diagnosis are less favourable compared to LMM, suggesting that non-solar melanoma is more aggressive than solar-related melanoma and that sentinel lymph node biopsy should be performed.