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Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging Volume 28, issue 3, May-June 2018

Figure 1

A) Difference in global assessment of photoaging at each visit compared to baseline. B) Difference in periorbital wrinkles at each visit compared to baseline. C) Difference in ephelides/melanosis at each visit compared to baseline. D) Difference in forehead wrinkles at each visit compared to baseline. The numbers (-4 to 4) in the legends represent the difference at each visit compared to baseline (0 = no difference, -1 = a one-point improvement, and 1 = a one-point worsening).

Figure 2

Improvement in overall skin pigmentation and fine wrinkles in an individual with adapalene treatment. A) Frontal view: Visit 1 (pre-treatment) and Visit 8 (24 weeks). B) Side view: Visit 1 (pre-treatment) and Visit 8 (24 weeks).

Figure 3

Improvement in overall skin pigmentation and fine wrinkles in an individual with tretinoin treatment. A) Frontal view: Visit 1 (pre-treatment) and Visit 8 (24 weeks). B) Side view: Visit 1 (pre-treatment) and Visit 8 (24 weeks).

Figure 4

A, B) Histology (H&E; magnification: 40×) showingcompaction and reduction of the thickness of the stratum corneum and increase in the thickness of the epithelium: A) pre-treatment; B) after 24 weeks of adapalene 0.3%. C, D) Immunostaining for collagen type I showing an increase in the density of collagen type I at the papillary dermis: C) pre-treatment; D) after 24 weeks of adapalene 0.3% (magnification: ×100).